Ngeminyaka yawo-1990, i-Pfizer yahola ekuthuthukiseni nasekufakeni ohlwini umkhiqizo wokuqala emhlabeni wegobolondo le-capsule engeyona i-gelatin, impahla eluhlaza eyinhloko okuyi-cellulose ester "hydroxypropyl methyl cellulose" evela ezitshalweni.Ngenxa yokuthi lolu hlobo olusha lwe-capsule alunazo izithako zezilwane, lunconywa yimboni ngokuthi "i-capsule yesitshalo".Njengamanje, nakuba umthamo wokuthengisa wamaphilisi ezitshalo emakethe ye-capsule yamazwe ngamazwe ungekho phezulu, ukuthuthukiswa kwawo kunamandla kakhulu, kunendawo yokukhula kwemakethe ebanzi.
　　
"Ngokuthuthukiswa kwesayensi yezokwelapha kanye nobuchwepheshe kanye nesayensi ehlobene, ukubaluleka kwezakhi zemithi ekukhiqizeni amalungiselelo emithi kuye kwaqashelwa kancane kancane, futhi isimo sekhemisi siyanda."U-Ouyang Jingfeng, ongumcwaningi ohlangene e-Chinese Academy of Chinese Medical Science, uveze ukuthi abasiza bemithi abagcini nje ngokunquma ikhwalithi yamafomu emithamo emisha kanye namalungiselelo amasha ezidakamizwa ngezinga elikhulu, kodwa futhi basiza ukulungiswa ukwakha, ukuzinza, ukuncibilika. , ukwandisa ukuncibilika, ukunweba ukukhululwa, ukukhululwa okuqhubekayo, ukukhululwa okulawulwayo, ukuma, isikhathi, ukuma, ukwenza ngokushesha, ukusebenza kahle nokuthatha isikhathi eside, futhi ngomqondo othile, ukuthuthukiswa komsizi omusha omuhle kakhulu kungaholela ekuthuthukisweni kwekilasi elikhulu. amafomu omthamo, athuthukise ikhwalithi yenani elikhulu lemithi emisha namalungiselelo, futhi ukubaluleka kwawo kudlula kude ukuthuthukiswa komuthi omusha.Emafomini omthamo wemithi njengamaphilisi kakhilimu, amaphilisi, imijovo, namaphilisi, amaphilisi asephenduke izinhlobo eziyinhloko zomthamo wamalungiselelo aqinile omlomo ngenxa ye-bioavailability yawo ephezulu, ukuthuthukisa ukuzinza kwezidakamizwa, kanye nokuma okunesikhathi nokukhululwa kwezidakamizwa.

Njengamanje, izinto eziyinhloko zokukhiqiza ama-capsules yi-gelatin, i-gelatin yenziwe nge-hydrolysis yamathambo ezilwane nezikhumba, futhi iyi-macromolecule ye-biological ene-ternary spiral structure, ene-biocompatibility enhle kanye nezakhiwo zomzimba namakhemikhali.Kodwa-ke, amaphilisi e-gelatin nawo anemikhawulo ethile ekusebenziseni, futhi ukwakhiwa kwezinto ezintsha zamagobolondo we-capsule angewona awesilwane sekuphenduke indawo eshisayo ocwaningweni lwakamuva lwezinto ezisizayo zemithi.U-Wu Zhenghong, uprofesa e-China Pharmaceutical University, uthe ngenxa “yesifo senkomo esihlanyayo” emazweni ase-Europe afana ne-britain, i-France ne-Netherlands ngeminyaka yawo-1990 (kuhlanganise ne-Japan yase-Asia, nayo eyathola izinkomo ezihlanyayo ezine-mad cow disease) , abantu bamazwe aseNtshonalanga bebengayethembi kakhulu inyama yenkomo nemikhiqizo ehlobene nezinkomo (i-gelatin nayo ingenye yazo).Ngaphezu kwalokho, amaBuddha kanye nabadla imifino baphinde bamelane namaphilisi e-gelatin enziwe ngezinto zokusetshenziswa zezilwane.Ngenxa yalokhu, ezinye izinkampani ze-capsule zakwamanye amazwe zaqala ukufunda izinto ezintsha zamagobolondo we-capsule we-non-gelatin neminye imithombo yezilwane, futhi ukubusa kwama-capsules we-gelatin bendabuko kwaqala ukuntengantenga.

Ukuthola izinto ezintsha zokulungiselela amaphilisi angewona awe-gelatin kuwukuthuthuka kwamanje kwezinto ezisizayo zemithi.U-Ouyang Jingfeng uveze ukuthi izinto zokusetshenziswa zamaphilisi ezitshalo okwamanje ziyi-hydroxypropyl methylcellulose, isitashi esilungisiwe kanye nezinye iglue zokudla ze-hydrophilic polymer, njenge-gelatin, i-carrageenan, i-xanthan gum nokunye.Amaphilisi e-Hydroxypropyl methyl cellulose ane-solubility efanayo, ukuhlakazeka kanye nokutholakala kwe-bioavailability kuma-gelatin capsules, kuyilapho enezinzuzo ezithile ama-gelatin capsules angenazo, kodwa ukusetshenziswa kwamanje akukabi kakhulu kakhulu, ikakhulukazi ngenxa yentengo ephezulu yomkhiqizo, uma kuqhathaniswa ne-gelatin, Izindleko ze-hydroxypropyl methyl cellulose capsule impahla eluhlaza ziphezulu, ngaphezu kwejubane lejeli elihamba kancane, okuholela kumjikelezo omude wokukhiqiza.

Emakethe yezemithi yomhlaba, amaphilisi ezitshalo angomunye wemikhiqizo ekhula ngokushesha.UWu Zhenghong uthe uma kuqhathaniswa namaphilisi e-gelatin, amaphilisi ezitshalo anezinzuzo ezilandelayo ezisobala: Okokuqala, akukho ukusabela okuphambanayo.Amaphilisi ezitshalo anokungasebenzi kahle futhi akulula ukuphambana namaqembu e-aldehyde noma ezinye izinhlanganisela.Eyesibili ifanele izidakamizwa ezingezwani namanzi.Umswakama wama-capsules wezitshalo ngokuvamile ulawulwa phakathi kuka-5% no-8%, futhi akulula ukusabela ngamakhemikhali nokuqukethwe, futhi okuqukethwe kwamanzi aphansi kuqinisekisa ukuzinza kokuqukethwe kwe-hygroscopic okungenwa kalula umswakama.Okwesithathu ukuhambisana okuhle nezinto ezisizayo zemithi.Amaphilisi emifino anokuhambisana okuhle ne-lactose, i-dextrin, isitashi, i-microcrystalline cellulose, i-magnesium stearate nezinye izinto ezisiza kakhulu ezisetshenziswa ekhemisi.Okwesine ukuba nendawo yokugcwalisa ekhululekile.Amaphilisi ezitshalo anezidingo ezixekethile ezixegayo zendawo yokusebenza kokuqukethwe okugcwele, kungakhathaliseki ukuthi yizidingo zendawo yokusebenza noma izinga lokuphasa emshinini, elinganciphisa izindleko zokusetshenziswa.
　
　
"Emhlabeni, ama-capsules ezitshalo asesencane, amabhizinisi ambalwa kakhulu angakhiqiza amaphilisi emithi yezitshalo, futhi kuyadingeka ukuqhubeka nokuqinisa ucwaningo ezinkambisweni zokukhiqiza nezinye izici, kuyilapho futhi ukwandisa imizamo yokukhuthaza imakethe."U-Ouyang Jingfeng uveze ukuthi okwamanje, ukukhiqizwa kwamaphilisi e-gelatin e-China sekufike endaweni yokuqala emhlabeni, kanti isabelo semakethe semikhiqizo ye-capsule yezitshalo sisaphansi.Ngaphezu kwalokho, ngenxa yokuthi isimiso senqubo yokukhiqiza ama-capsules ayikashintshi iminyaka engaphezu kwekhulu, futhi ukuthuthukiswa okuqhubekayo kwemishini yakhelwe ngokuya ngenqubo yokukhiqiza i-gelatin, indlela yokusebenzisa inqubo kanye nemishini yokulungiselela ama-capsules we-gelatin ukulungisa isitshalo. ama-capsules abe yinto okugxilwe kuyo ucwaningo, okubandakanya ukutadisha okuqondile kwezakhi zenqubo ezifana ne-viscosity, izakhiwo ze-rheological kanye ne-viscoelasticity yezinto.
　　

Nakuba kungenakwenzeka ukuthi amaphilisi ezitshalo athathe isikhundla sokubusa kwamaphilisi e-gelatin angenalutho, amaphilisi ezitshalo anezinzuzo ezisobala zokuncintisana emalungiselelweni emithi yendabuko yaseShayina, amalungiselelo ebhayoloji kanye nokudla okusebenzayo.U-Zhang Youde, unjiniyela omkhulu eSikoleni Sesayensi Yezinto Zokusebenza Nobunjiniyela saseBeijing Institute of Technology, ukholelwa ukuthi ngokuqonda kwabantu okujulile ngamaphilisi ezitshalo kanye nokuguqulwa komqondo womphakathi wezidakamizwa, isidingo semakethe samaphilisi ezitshalo sizokhula ngokushesha.