(1)Izinto zokusetshenziswa

Impahla eluhlaza ye-HPMC capsule engenalutho itholakala ikakhulukazi ku-fiber yezitshalo zemvelo (isihlahla sikaphayini), esinobungani nemvelo, esiphephile futhi esithembekile.

I-Gelatin capsule engenalutho itholakala ikakhulukazi ku-collagen esikhumbeni sezilwane namathambo.Enqubweni yokukhipha, inani elikhulu lezingxenye zamakhemikhali zengezwa, okulula ukwethula amagciwane e-mad cow disease kanye nesifo sonyawo nomlomo, njll.,.Eminyakeni yamuva, isigameko se-"Poison Capsule" siye sadalula izinkinga eziningi ze-gelatin capsules yendabuko, njenge-"glue yesikhumba eluhlaza okwesibhakabhaka" evezwe abezindaba, okwenza i-chromium ku-capsule idlule izinga.

(2) Ukusebenza Nokuqina Kwekhemikhali

I-HPMC iwukuphuma kwe-cellulose okunamandla okungenzi lutho, ukusebenza okubanzi, izici zamakhemikhali ezizinzile, akukho ukusabela okuxhumanisa okuphambene nezidakamizwa ezine-aldehyde, futhi akukho ukubambezeleka kokuhlukana.

I-Lysine ihlala ku-gelatin, Uma usebenzisa i-gelatin ku-capsule, kuzoba nokubambezeleka kokuhlakazeka.Okuqukethwe kwezidakamizwa ezehlisa kakhulu kuzoba nokusabela kwe-Maillard nge-gelatin (I-Browning Reaction).Uma umuthi oqukethe i-aldehyde, ikhemikhali esuselwe kushukela encishisiwe, noma uvithamini C, ngakho-ke awufanelekile ukusetshenziswa ku-gelatin engenalutho capsule.

(3) Okuqukethwe kwamanzi

Okuqukethwe kwamanzi kwe-gelatin hollow capsule cishe ku-12.5% ​​kuya ku-17.5%.I-gelatin capsule enokuqukethwe okuphezulu kwamanzi ijwayele ukumunca umswakama wokuqukethwe kwezidakamizwa noma ukumuncwa amanzi ngokuqukethwe kwayo kokugcwalisa, okwenza i-capsule ithambile noma i-brittle, ethinta umuthi ogcwele ngokwawo.

Okuqukethwe kwamanzi kwe-capsule engenalutho ye-HPMC cishe ku-3% kuya ku-9%, engeke iphendule okuqukethwe kokugcwalisa, futhi ingagcina izakhiwo ezinhle zomzimba ezifana nokuqina lapho ugcwalisa okuqukethwe kwezidakamizwa zezakhiwo ezahlukene, Ikakhulukazi ifanele i-hygroscopicity kanye nokugcwaliswa komswakama. izidakamizwa ezibucayi.

(4) Izinsalela ezilondolozayo

Ingxenye eyinhloko ye-gelatin hollow capsule iphrotheni, okulula ukuzalanisa amagciwane nama-microorganisms.Ama-preservatives kanye nama-bacteriostatic agents, angase ashiywe ku-capsule ukuvimbela ukukhula kwamagciwane ngesikhathi sokukhiqiza.Uma inani lidlula ububanzi obuthile, okuqukethwe kwe-arsenic kungase kudlulwe ekugcineni.Ngesikhathi esifanayo, ama-capsules angenalutho we-gelatin adinga ukuvalwa inzalo nge-ethylene oxide ngemva kokuqedwa kokukhiqizwa, futhi kuzoba ne-chlorohydrin ngemva kokuvalwa kwe-ethylene oxide.Ngenkathi izinsalela ze-Chlorohydrin zinqatshelwe ukusetshenziswa.

Amaphilisi angenalutho e-HPMC awadingi ukungeza noma yiziphi izivimbelakuvunda ohlelweni lokukhiqiza, awadingi ukuvalwa inzalo, angahlangabezana ngokugcwele nezindinganiso zikazwelonke, futhi angamaphilisi aluhlaza anempilo ngaphandle kwanoma yiziphi izinsalela nezivimbelakuvunda.

(5) Isitoreji

Ama-capsules angenalutho e-HPMC anezimo zokugcinwa okuxekethile, ezingeni lokushisa elingu-10 kuya ku-30 ​​° C, kanye nomswakama ophakathi kuka-35% no-65%, ongathambisi noma uqine futhi abe brittle.I-capsule ye-HPMC engenalutho inokushisa okungu-≤ 2% kumswakama we-35% kanye noshintsho lwe-capsule ≤ 1% ekushiseni kuka-80 ° C;Ukugcina nokuthutha kuzo zonke izindawo ezinesimo sezulu akuyona inkinga.

Ama-capsules e-Gelatin athambekele ekunamatheleni ngaphansi kwezimo ezinomswakama ophezulu;ukuqina noma ukuqina ngaphansi kwezimo ezinomswakama ophansi, futhi incike kakhulu kuzinga lokushisa kanye nomswakama wendawo yokugcina

(6) Abanobungani bemvelo

Ukukhishwa kwe-HPMC okungenalutho kwe-capsule impahla eluhlaza kwenziwa ngokukhipha ngokomzimba.Ikhishwa esihlahleni sikaphayini futhi ayikhiphi iphunga elibi.Futhi kunciphisa kakhulu inani lamanzi asetshenziswayo futhi kunciphisa ukungcoliswa kwemvelo.Azikho izinto eziyingozi ezengezwayo phakathi nenqubo futhi akukho ukungcoliswa kwemvelo.

Ama-capsules angenalutho e-gelatin enziwe ngesikhumba sesilwane kanye nethambo njengezinto zokusetshenziswa, ezithintekayo ngamakhemikhali futhi zivutshiwe.Inqubo yengeza inani elikhulu lezingxenye zamakhemikhali, ikhiqiza iphunga elikhulu ngesikhathi sokukhiqiza, futhi isebenzisa inani elikhulu lemithombo yamanzi.Ukukhiqiza ukungcola okubi kakhulu;Futhi ukugaywa kabusha kwemfucuza ye-gelatin kuphansi, futhi inani elikhulu lemithombo yokungcola likhiqizwa ngesikhathi sokulahlwa kwemfucuza yayo.

(7) Ukuhlukanisa ukuxhumana nomoya wangaphandle

Izinto ezisetshenziswayo zokusetshenziswa zamaphilisi angenalutho e-HPMC anquma ukuthi angakwazi ukuhlukanisa ngokuphumelelayo okuqukethwe ezweni langaphandle futhi agweme imiphumela emibi ngomoya, futhi ukuphila kwayo kweshalofu ngokuvamile kuyizinyanga ezingu-24.

I-gelatin capsule inesikhathi esisebenzayo sezinyanga ezingaba ngu-18, kuyilapho kukhona nesikhathi sokugcina ngaphambi kokusetshenziswa kwenza i-capsule ibe nempilo yeshalofu emfushane, ethinta ngokuqondile impilo yeshalofu yomuthi.

(8) Ukuvimbela ukukhula kwamagciwane

Impahla eyinhloko yama-capsules angenalutho e-HPMC i-fiber yezitshalo, engagcini nje ngokukhulisa amagciwane, kodwa futhi ivimbela ukukhula kwamagciwane.Ukuhlola kubonise ukuthi amaphilisi angenalutho e-HPMC angagcinwa endaweni evamile isikhathi eside, futhi inani lama-microorganisms lingagcinwa ngaphansi kwebanga elijwayelekile.

Impahla eluhlaza eyinhloko ye-gelatin hollow capsule yi-collagen, futhi i-collagen iyindlela yokwelapha yebhaktheriya, esiza amagciwane ukuthi aphindaphindeke.Uma ukwelashwa kungalungile, inani lamabhaktheriya lizodlula izinga futhi lizophindaphinda.

Qeda.